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KMID : 1007520120210051507
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Food Science and Biotechnology
2012 Volume.21 No. 5 p.1507 ~ p.1510
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Japanese Apricot Extract Attenuates Nuclear Factor-κB Activation and Proteasomal Activity in A549 Lung Cancer Cells
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Yoon Hyung-Eun
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Abstract
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The present study investigated the mechanism of Japanese apricot extract (JAE) in inhibiting lung cancer cells proliferation. JAE inhibited A549 lung cancer cell proliferation at non-cytotoxic doses and suppressed nuclear factor-KB (NF-KB) activation induced by TNF-α at a dose of 1 mg/mL (p<0.05). Proteasome activities of A549 cells were blocked by JAE in a dose-dependent manner at concentrations of 0.67 and 1 mg/mL (p<0.05). These results indicate that JAE has anti-proliferative activity against A549 cells and suppresses NF-KB activation, partially due to inhibiting proteasome activity.
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KEYWORD
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Japanese apricot, lung cancer, nuclear factor KB, proteasome
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